GLP-1 medications like Ozempic, Wegovy, and Mounjaro have completely changed the game for weight loss and metabolic health. But while the results on the scale may be impressive, many patients are noticing an unexpected side effect: changes in their face. “Ozempic Face” has become a buzzword on social media, and in my practice, it’s become one of the most common aesthetic concerns among patients using these medications. If you’re using or considering GLP-1s, it’s important to understand how they can affect your facial appearance — and most importantly, what you can do to prevent or treat it.

Ozempic Face refers to the loss of volume and youthful fullness in the face following rapid weight loss, particularly weight loss triggered by GLP-1 medications. These drugs don’t just target belly fat or unwanted weight around the hips — they work systemically, meaning you also lose the soft, supportive fat pads in your face. This can lead to sunken cheeks, more pronounced nasolabial folds, visible bone structure, and sagging skin, especially in the lower face and jawline. Patients often describe a disconnect between how they feel physically and how they look in the mirror: “I’ve never been healthier, but I look tired and older.” This emotional response is very real, and it deserves thoughtful, medically-informed solutions.

The first signs of Ozempic Face are often subtle — a bit more hollowness under the eyes, makeup that doesn’t sit quite right, or comments from others like, “Are you getting enough sleep?” Over time, these signs can become more dramatic: hollow cheeks, loss of definition in the midface, thinning at the temples, and skin laxity that creates jowling or marionette lines. These changes aren’t just about fat loss — they’re about the architecture of your face being altered without the natural scaffolding that once supported it.

So what can be done? The good news is: a lot. In my clinic, we treat Ozempic Face by first restoring volume in the midface and cheekbone area. This helps lift the face, support the under eyes, and improve the contour of the cheek. We then address volume loss in the buccal space, jawline, and temples to restore balance and structure. This is done with strategic, layered filler techniques that look natural and preserve facial identity.

Beyond filler, we also use regenerative treatments that go deeper than surface-level correction. Collagen stimulators like Radiesse and Sculptra help the body regenerate its own collagen over time, improving skin quality and firmness. One of my favorite treatments is Renuva, a regenerative fat matrix that encourages the body to replace lost facial fat with natural tissue. These options allow us to rebuild the face in a way that’s gradual, lasting, and harmonious with your natural beauty.

It’s also essential to understand the importance of prevention. If you’re just beginning your weight loss journey, or are considering starting GLP-1 medications, the best time to start thinking about your face is now. Preventative treatment — even just small touchpoints — can make a dramatic difference in preserving your natural structure as your body changes. We can create a custom preservation plan to support your skin and volume so that your results stay consistent, both in the mirror and on the scale.

But if you’ve already started weight loss and are noticing changes, don’t worry — it’s not too late. We see patients every day who’ve been on GLP-1s for months or years, and we’re still able to restore what’s been lost. The key is choosing an injector who understands facial anatomy, regenerative science, and the emotional component of aesthetic transformation.

Ozempic Face is real, and it’s more common than you think. But with the right tools, timing, and expertise, it doesn’t have to define your weight loss journey. Whether you’re looking to prevent volume loss or reverse facial hollowing, there are options available that can help you feel just as radiant as you feel healthy.

If this sounds familiar to you, or if you’re curious about how to protect your facial integrity during your health transformation, I invite you to come see me. Let’s create a personalized plan that celebrates your beauty at every stage. You deserve to feel strong, confident, and seen.