NAD+: From Cellular Science to Beauty Buzz…

NAD+ has been studied for decades but has recently made its way to the front row of the beauty scene.. but why? Well, NAD+ is short for nicotinamide adenine nucleotide (now we know why there’s an abbreviation- isn’t that a mouth full?) and is a coenzyme that is critical for energy production, DNA repair, and overall cellular function. Basically, this means that NAD+ helps mitochondria (hello powerhouse of the cell!) to function properly. As we get older, NAD+ levels become depleted and our mitochondria become very sad which leads to visible aging. The obvious solution is to just bring those NAD+ levels right back!

How to Restore NAD+ Levels in the Body

 NAD+ can be administered via injections, nasal sprays, IV infusions, oral supplements, and topical formulas- with some options working better than others. Oral NAD+ supplements are easily broken down by the digestive system before they get to take effect. Therefore, it’s crucial to opt for compounds that will be converted into NAD+ inside the body instead. Some examples of these compounds are nicotinamide mononucleotide, nicotinamide riboside, and niacinamide. While exact data is still in the works, it’s showing that combining internal methods with topical support is the most effective way to help repair skin barriers, stimulate collagen production, and defend cells against oxidative stress. 

Safety Considerations Before Starting NAD+ Therapy

However, NAD+ isn’t all sunshines and rainbows. It is generally safe with minimal side effects, but it can cause some flushing. For this reason, NAD+ should be approached with caution in patients with sensitive skin or rosacea as it can worsen their condition. It’s also important to screen patients carefully- because if something benefits healthy cells, there is a chance it may benefit cancerous cells as well (and we definitely don’t want that)! That said, underlying cancer risks is a huge factor to take into account before beginning NAD+ therapy.